Quad Cities has 742 employees that live in the Quad Cities area. During refueling outages, the power plant employs several hundred temporary contractors who boost the local economy during their stay. The center's annual payroll is approximately $78 million.

Quad Cities also supports 4,200 direct and secondary jobs in Illinois. The facilities’ output also stimulates Illinois’ labor income and employment.

Illinois’ nuclear facilities contribute nearly $9 billion to the state’s economy annually, with Quad Cities contributing $11.5 million in property taxes annually. The greatest impact in Illinois is on the professional, scientific and technical sectors due to the volume of specialized services required to operate a nuclear energy facility.